Anatomy & Physiology NCLEX-PN Practice Quiz

163 NCLEX-PN style questions across all major body systems — cardiovascular, respiratory, renal, GI, endocrine, neuro, hematology, immune, musculoskeletal, integumentary, sensory, and reproductive. Instant feedback and detailed rationales after each question.

✓ 163 Questions ✓ NCLEX-PN Style ✓ 100% Free
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163 questions modeled after the Exit Exam format — pick how many below.

About This Anatomy & Physiology Practice Test

This free Anatomy and Physiology practice test covers every body system you are tested on as an LPN/LVN student — cardiovascular, respiratory, nervous, renal and urinary, digestive, endocrine, musculoskeletal, integumentary, hematologic and immune, reproductive, and the special senses. Every question is written in NCLEX-PN style and comes with a full rationale explaining why the correct answer is correct and why the other options are not.

What This Quiz Covers

Sample Questions

Five questions pulled straight from this quiz, with the same rationales you get after every answer.

1. Which of the following occurs at the beginning of systole in a healthy heart?

  • AThe mitral valve opens
  • BThe ventricles contract
  • CThe tricuspid valve opens
  • DThe atria fill with blood
Show answer & rationale
Correct answer: B

Systole begins with ventricular contraction. During this phase, the mitral and tricuspid valves close (producing S1, the 'lub' sound), and blood is ejected through the aortic and pulmonic valves into the great vessels. The atria fill during ventricular systole.

2. Which of the following structures of the respiratory system is the site of gas exchange?

  • APleurae
  • BTrachea
  • CAlveoli
  • DBronchioles
Show answer & rationale
Correct answer: C

The alveoli are tiny air sacs at the end of the bronchial tree where gas exchange occurs. Oxygen diffuses from the alveoli into the pulmonary capillaries, and carbon dioxide diffuses from the blood into the alveoli to be exhaled. The alveoli are surrounded by a dense network of capillaries to maximize surface area for exchange.

3. Bile aids in the digestion of which of the following?

  • AProtein
  • BFat
  • CCarbohydrates
  • DVitamins
Show answer & rationale
Correct answer: B

Bile is produced by the liver, stored in the gallbladder, and released into the duodenum when fatty food is present. Bile emulsifies fat -- breaking large fat globules into smaller droplets so that pancreatic lipase can more effectively digest them. Without bile, fat-soluble vitamins (A, D, E, K) cannot be absorbed.

4. Which of the following parts of the central nervous system is responsible for the control of involuntary respirations?

  • ACerebellum
  • BCerebrum
  • CMedulla oblongata
  • DThalamus
Show answer & rationale
Correct answer: C

The medulla oblongata, located in the brainstem, controls vital involuntary functions including respiratory rate, heart rate, blood pressure, and reflexes such as coughing, sneezing, swallowing, and vomiting. Damage to the medulla is often incompatible with life because these automatic functions cease.

5. A nurse is reviewing the effects of liver failure. Which of the following are expected when the liver can no longer perform its normal functions? Select all that apply.

  • AIncreased bleeding risk
  • BElevated serum albumin
  • CJaundice
  • DElevated blood ammonia and confusion
  • EIncreased production of clotting factors
  • FImproved absorption of dietary fat
Show answer & rationale
Correct answers: A, C, D (select all that apply)

The liver makes clotting factors (fewer factors -> bleeding risk), clears ammonia (buildup -> confusion and hepatic encephalopathy), and processes bilirubin (buildup -> jaundice). It also makes albumin, and in failure albumin FALLS rather than rises -- the low albumin is exactly what pulls fluid into the tissues and abdomen, producing edema and ascites. The liver produces FEWER clotting factors in failure, and with no bile reaching the gut fat absorption WORSENS (fatty, clay-colored stools).

Frequently Asked Questions

Are these Anatomy & Physiology practice questions really free?

Yes. All 163 questions are free to use, with no account, no sign-up, and no card. You can retake the quiz as many times as you like.

Will this help with my ATI or HESI exit exam?

It should. Nursing school exit exams such as the ATI PN Comprehensive Predictor and the HESI PN Exit Exam are built to predict NCLEX-PN readiness, so they draw on the same content areas these questions follow. The question formats differ, but the material overlaps heavily.

Do the questions come with rationales?

Every one does. As soon as you answer, you see whether you were right along with a full explanation of the reasoning, including why the other options are wrong.

How long is the Anatomy & Physiology practice test?

You choose. Take a short set of 10 for a quick review, or work through the full pool of 163 questions as a longer practice test. You can also filter by topic to drill a single area.

Want to review before you test yourself? Read the Anatomy & Physiology study guides, or browse all 8 subject quizzes.

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